Lista de Artigos Científicos Relevantes.
Avanços científicos publicados em revistas internacionais da especialidade


Artigos de opinião e revisão

Wagner JE, Gluckman E.
Umbilical cord blood transplantation: the first 20 years. Semin Hematol. 2010 Jan;47(1):3-12.

Seres KB, Hollands P.
Reprod Biomed Online.2010 Jan;20(1):98-102. Epub 2009 Oct 30. Cord blood: the future of regenerative medicine?

Hollands P, McCauley C.
Private cord blood banking: current use and clinical future. Stem Cell Rev. 2009 Sep;5(3):195-203. Epub 2009 Jul 15. Review.

Gluckman E.
History of cord blood transplantation. Bone Marrow Transplant. 2009 Nov;44(10):621-6. Epub 2009 Oct 5. Review.

Gluckman E, Rocha V.
Cord blood transplantation: state of the art. Haematologica. 2009 Apr;94(4):451-4. Review.

Navarrete C, Contreras M.
Cord blood banking: a historical perspective. Br J Haematol. 2009 Oct;147(2):236-45.

Harris DT, Rogers I.
Umbilical cord blood: a unique source of pluripotent stem cells for regenerative medicine. Curr Stem Cell Res Ther. 2007 Dec;2(4):301-9. Review.

The potential of umbilical cord blood multipotent stem cells for nonhematopoietic tissue and cell regeneration.
van de Ven C, Collins D, Bradley MB, Morris E, Cairo MS. Exp Hematol. 2007 Dec;35(12):1753-65. Epub 2007 Oct 18. Review.

Expanding the role of umbilical cord blood transplantation.
Brunstein CG, Setubal DC, Wagner JE. Br J Haematol. 2007 Apr;137(1):20-35. Review.

O´Brien et al (2006)
No longer a biological waste product: umbilical cord blood. Med J Aust. 184(8): 407-10

Rubinstein P (2006)
Why cord blood? Human Immun. 67:398-404

Moise KJ (2006)
Umbilical Cord Stem Cells Obstetrics and Gynec. 106(6): 1393-1407

Agarwal MB (2006)
Umbilical cord blood transplantation: newer trends. JAPI 54: 143-147

Brunstein CG (2006)
Umbilical cord blood transplantation and banking. Annu Rev Med. 57: 403-417

Rocha V et al (2006)
Clinical Use of umbilical cord blood hematopoietic stem cells. Biol Blood and Marrow Transp. 12:34-41

Gluckman E (2006)
Cord blood transplantation. Biol Blood Marrow Transp. 12:808-812

Gluckman E, Rocha V (2005)
History of the clinical use of umbilical cord blood hematopoietic cells. Cytotherapy 7(3): 219-27

Broxmeyer HE (2005)
Biology of cord blood cells and future prospects for enhanced clinical benefit. Cytotherapy 7(3): 209-218

Watt SM et al (2005)
Stem cell medicine: umbilical cord blood and its stem cell potential. Sem. Fetal and Neonatal Med. 10:209-220

 

Panorama da transplantação hematopoiética na Europa

Gratwohl A, Baldomero H.
Trends of hematopoietic stem cell transplantation in the third millennium. Curr Opin Hematol. 2009 Nov;16(6):420-6.

Gratwohl A, Baldomero H, Schwendener A, Rocha V, Apperley J, Frauendorfer K, Niederwieser D; Joint Accreditation Committee of the International Society for Cellular Therapy; European Group for Blood and Marrow Transplantation. The EBMT activity survey 2007 with focus on allogeneic HSCT for AML and novel cellular therapies. Bone Marrow Transplant. 2009 Feb;43(4):275-91. Epub 2009 Jan 26.

Gratwohl A et al (2005)
Change in stem cell source for hematopoietic stem cell transplantation (HSCT) in Europe: a report of the EBMT activity survey 2003. Bone Marrow Transplant 36: 575-590

Gratwohl A et al (2004)
Haematopoietic stem cell transplantation (HSCT) in Europe 2002. Change in indication and impact of team density. A report of the EBMT activity survey. Bone Marrow Transplant 34: 858-875

Gratwohl A et al (2002)
Current trends in hematopoietic stem cell transplantation in Europe. Blood 100(7): 2374-2386

 

Transplante com sangue do cordão umbilical em adultos

Brunstein CG, Laughlin MJ.
Extending cord blood transplant to adults: dealing with problems and results overall. Semin Hematol. 2010 Jan;47(1):86-96

Ooi J.
Cord blood transplantation in adults.Bone Marrow Transplant. 2009 Nov;44(10):661-6. Epub 2009 Oct 5. Review.

Schoemans H, Theunissen K, Maertens J, Boogaerts M, Verfaillie C, Wagner J.
Adult umbilical cord blood transplantation: a comprehensive review. Bone Marrow Transplant. 2006 Jul;38(2):83-93. Epub 2006 Jun 5. Review.

Arcese W, Rocha V, Labopin M, Sanz G, Iori AP, de Lima M, Sirvent A, Busca A, Asano S, Ionescu I, Wernet P, Gluckman E; Eurocord-Netcord Transplant group.
Unrelated cord blood transplants in adults with hematologic malignancies. Haematologica. 2006 Feb;91(2):223-30.

Tse W, Laughlin M (2005)
Cord blood transplantation in adult patients. Cytotherapy 7:228-242

Lane TA (2005)
Umbilical cord blood grafts for hematopoietic transplantation in adults: a cup half empty or half full? Transfusion 45:1027-1034

Laughlin et al (2004)
Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. New Engl J Med, 351 (22): 2265-2275.

Rocha V et al (2004)
Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. New Engl J Med, 351 (22): 2276-2285

Takahashi et al (2004)
Single-institute comparative analysis of unrelated bone marrow transplantation and cord blood transplantation for adult patients with hematologic malignancies. Blood 104:3813-3820

 

Expansão de células estaminais do sangue do cordão umbilical

Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID.
Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med. 2010 Feb;16(2):232-6. Epub 2010 Jan 17.

de Lima M et al (2006)
Strategies for widening the use of cord blood in hematopoietic stem cell transplantation. Haematologica 91(5): 584-588

Astori G et al (2006)
Ex vivo expansion of umbilical cord blood CD34+ cells in a closed system: a ulticentric study. Vox Sanguinis 90: 183-190

Parmer S et al (2006)
Ex vivo expanded umbilical cord blood T cells maintain naïve phenotype and TCR diversity. Cytotherapy 8(2): 149-157

Robinson SN et al (2006)
Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transp. 1-8

Suzuki T et al (2006)
Highly efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc chimeric protein. Stem Cells Stem Cells. 2006 Nov;24(11):2456-65. Epub 2006 Jul 20.

 

Transplante autólogo com células estaminais do sangue do cordão umbilical

Hayani A, Lampeter E, Viswanatha D, Morgan D, Salvi SN.
First report of autologous cord blood transplantation in the treatment of a child with leukemia. Pediatrics. 2007 Jan;119(1):e296-300.

Thornley I et al (2004)
Family cord blood banking: experience and views of pediatric hematopoietic stem cell transplant physicians. Blood 104(11):3323

Fruchtman et al (2004)
The successful treatment of severe aplastic anemia with autologous cord blood transplantation. Biol Blood Marrow Transplant, 10(11):741-2

Hough RE et al (2003)
Successful neutrophil recovery following autologous umbilical cord blood. Blood 102(11): 5306

Kaufman et al (2002)
Outcome data from eleven consecutive hematopoietic stem cell transplants, nine allogenic and two autologous, using units from a family cord blood banking service, 44th ASH Annual Meeting

Ferreira E et al (1999)
Autologous cord blood transplantation. Bone Marrow Transplant, 24: 104

Kohn et al (1995)
Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. Nat Med, 2(10):1017-23

 

Probabilidade de transplante autólogo

Nietfeld JJ, Pasquini MC, Logan BR, Verter F, Horowitz MM. On the probability of using cord blood. Biol Blood Marrow Transplant. 2008 Jun;14(6):724-5.

Nietfeld JJ, Pasquini MC, Logan BR, Verter F, Horowitz MM.
Lifetime probabilities of hematopoietic stem cell transplantation in the U.S. Biol Blood Marrow Transplant. 2008 Mar;14(3):316-22.

Pasquini MC (2005)
The Likelihood of Hematopoietic Stem Cell Transplantation in the United States: Implications for Umbilical Cord Blood Storage. Blood, 106: 1330

Annas GJ (1999)
Waste and longing – the legal status of placental-blood banking. N Eng J Med 340 (19): 1521-1524

Johnson FL (1997)
Placental blood transplantation and autologous banking- caveat emptor. J Ped Hem Onc 19(3): 183-186

 

Avanços científicos e potencial do sangue do cordão umbilical

Moon YJ, Yoon HH, Lee MW, Jang IK, Lee DH, Lee JH, Lee SK, Lee KH, Kim YJ, Eom YW. Multipotent progenitor cells derived from human umbilical cord blood can differentiate into hepatocyte-like cells in a liver injury rat model. Transplant Proc. 2009 Dec;41(10):4357-60.

Lee JH, Chang HS, Kang EH, Chung DJ, Choi CB, Lee JH, Hwang SH, Han H, Kim HY. Percutaneous transplantation of human umbilical cord blood-derived multipotent stem cells in a canine model of spinal cord injury. J Neurosurg Spine. 2009 Dec;11(6):749-57.

Liu G, Li Y, Sun J, Zhou H, Zhang W, Cui L, Cao Y. In vitro and in vivo evaluation of osteogenesis of human umbilical cord blood derived mesenchymal stem cells on partially demineralized bone matrix. Tissue Eng Part A. 2009 Oct 19. [Epub ahead of print]

Haller MJ, Viener HL, Wasserfall C, Brusko T, Atkinson MA, Schatz DA. Autologous umbilical cord blood infusion for type 1 diabetes. Exp Hematol. 2008 Jun;36(6):710-5. Epub 2008 Mar 20

Gao F, Wu DQ, Hu YH, Jin GX, Li GD, Sun TW, Li FJ. In vitro cultivation of islet-like cell clusters from human umbilical cord bloodderived mesenchymal stem cells. Transl Res. 2008 Jun;151(6):293-302. Epub 2008 Apr 28.

Cho S-W et al (2006) Enhancement of angiogenic efficacy of human cord blood cell transplantation. Tissue Eng. 12(6):1-11

Ma N et al (2006) Umbilical cord blood cell transplantation for myocardial regeneration. Trans Proc. 38:771-773

Buzanska L et al (2006) Neural stem-like cell line derived from a nonhematopoietic population of human umbilical cord blood. Stem Cells Dev. 15(3):391-406.

Chen HK (2005) Combined cord blood stem cells and gene therapy enhances angiogenesis and improves cardiac performance in mouse after myocardial infarction. Eur J Clin Inv 35:677-686

Leor J et al (2005) Human umbilical cord blood cells: a new alternative for myocardial repair? Cytotherapy 7(3): 251-257

Korbling M et al (2005) Umbilical cord blood-derived cells for tissue repair. Cytotherapy 7(3): 258-261

Yoshida S (2005) Human cord blood-derived cells generate insulin-producing cells in vivo. Stem Cells Devel 15: 391-406

Kang K-S (2005) A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human umbilical cord blood, with improved sensory perception and mobility, both functionally and morphologically: a case study. Cytotherapy 7(4): 368-373

Zhenhang N et al (2005) Infusion of human umbilical cord blood ameliorate neurologic deficits in rats with hemorrhagic brain injury. Ann N Y Acad Sci. 1049:84-96

Teramoto K et al (2005) Hepatocyte differentiation from embryonic stem cells and umbilical cord blood cells. J Hepat Panc Surg 12:196-202

Sharma AD et al (2005) Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver. Stem Cells Tissue Eng Hem Elem. 167(2):555-564

 

Outros artigos científicos relevantes

Low CB, Liou YC, Tang BL. Neural differentiation and potential use of stem cells from the human umbilical cord for central nervous system transplantation therapy. J Neurosci Res. 2008 Jun;86(8):1670-9.

Bachstetter AD, Pabon MM, Cole MJ, Hudson CE, Sanberg PR, Willing AE, Bickford PC, Gemma C. Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain. BMC Neurosci. 2008 Feb 14;9:22.

Kang KS, Kim SW, Oh YH, Yu JW, Kim KY, Park HK, Song CH, Han H. A 37-year-old spinal cord-injured female patient, transplanted of multipotent stem cells from human umbilical cord blood, with improved sensory perception and mobility, both functionally and morphologically: a case study. Cytotherapy 2005 7(4): 368-373

Ma N., Stamm C., Kaminski A., Li W., Kleine H.D., Muller-Hilke B., Zhang L., Ladilov Y., Egger D., Steinhoff G., Human cord blood cells induce angiogenesis following myocardial infarction in NOD/scid-mice. Cardiovasc Res, 2005, 66(1): 45-54.

Giarratana M.C., Kobari L., Lapillonne H., Chalmers D., Kiger L., Cynober T., Marden M.C., Wajcman H., Douay L., Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells. Nat Biotechnol., 2005, 23(1):69-74.

Schmidt D., Mol A., Neuenschwander S., Breymann C., Gossi M., Zund G., Turina M., Hoerstrup S.P., Living patches engineered from human umbilical cord derived fibroblasts and endothelial progenitor cells. Eur J Cardiothorac Surg. 2005, 27(5):795-800

Ballen K., New trends in umbilical cord blood transplantation, Blood, 2005, 105(10):3786-92.

“Private Cord Blood Banks”. Med Lett Drugs Ther. 2004 Mar 15;46(1178):21-22

McNiece I., Ex vivo expansion of hematopoietic cells. Exp Hematol, 2004, 32(5):409-10.

Laughlin M.J., Eapen M., Rubinstein P., Wagner J.E., Zhang M.J., Champlin R.E., Stevens C., Barker J.N., Gale R.P., Lazarus H.M., Marks D.I., van Rood J.J., Scaradavou A., Horowitz M.M., Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia. New Engl J Med, 2004, 351 (22): 2265-75.

Rocha V., Labopin M., Sanz G., Arcese W., Schwerdtfeger R., Bosi A., Jacobsen N., Ruutu T., de Lima M., Finke J., Frassoni F., Gluckman E., Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. New Engl J Med, 2004, 351 (22): 2276-85.

Sanz M.A., Cord-blood transplantation in patients with leukaemia – a real alternative for adults, N Engl J Med, 2004, 351(22):2328-30.

Fruchtman S.M., Hurlet A., Dracker R., Isola L., Goldman B., Schneider B.L., Emre S. ,
The successful treatment of severe aplastic anemia with autologous cord blood transplantation. Biol Blood Marrow Transplant, 2004, 11:741-2.

Kogler G., Sensken S., Airey J.A., Trapp T., Muschen M., Feldhahn N., Liedtke S., Sorg R.V., Fischer J., Rosenbaum C., Greschat S., Knipper A., Bender J., Degistirici O., Gao J., Caplan A.I., Colletti E.J., Almeida-Porada G., Muller H.W., Zanjani E., Wernet P., A new human somatic stem cell from placental cord blood with intrinsic pluripotent differentiation potential. J Exp Med, 2004, 200 (2): 123-35.

Oscar K. Lee, Tom K. Kuo, Wei-Ming Chen, Kuan-Der Lee, Shie-Liang Hsieh, Tain-Hsiung Chen, Isolation of multi-potent mesenchymal stem cells from umbilical cord blood, Blood. 2004 Mar 1;103(5):1669-75

Jang YK, Park JJ, Lee MC, Yoon BH, Yang YS, Yang SE, Kim SU., Retinoic acid-mediated induction of neurons and glial cells from human umbilical cord-derived hematopoietic stem cells., J Neurosci Res. 2004 Feb 15;75(4):573-84

Gammaitoni L, Weisel KC, Gunetti M, Wu KD, Bruno S, Pinelli S, Bonati A, Aglietta M, Moore MA, Piacibello W. Elevated telomerase activity, minimal telomere loss in cord blood long-term cultures with extensive stem cell replication. Blood. 2004 Jan 15

Yossi Cohen and Arnon Nagler, Cord Blood Biology and Transplantation, Isr. Med. Ass. Journal, vol 6, 39-46, 2004

Yossi Cohen and Arnon Nagler, Hematopoietic Stem-cell Transplantation Using Umbilical-cord, Blood, Leukemia & Lymphoma, Vol. 44, No 8 (August 2003), pp. 1287–1299

Hough R., MacMillan M., Ramsay N., Wagner J., “Successful neutrophil recovery following autologous umbilical cord (UCB) Transplantation for Hepatitis-Associated Aplastic Anemia: Case of Autologous UCB as Biological Insurance, 2003, (SAA)”, Blood 102(11), Abstract #5306

Barker J. & Wagner J., "Umbilical Cord Blood Transplantation: current practice and future innovations", Critical Reviews in Oncology/Hematology 48 (2003), 35-43

Wang X. et al., Albumin-expressing hepatocyte-like cells develop in the livers of immune-deficient mice that received transplants of highly purified human hematopoietic stem cells. Blood, 2003 May 15, 101(10): 4201-8

Kakinuma S. et al., Human umbilical cord blood as a source of transplantable hepatic progenitor cells. Stem Cells, 2003, 21(2): 217-27

Rosada C. et al.,The human umbilical cord blood: a potential source for osteoblast progenitor cells. Calcif. Tissue Int., 2003 Feb, 72(2): 135-42

Romanov Y.A., Searching for Alternative Sources of Postnatal Human Mesenchymal Stem Cells: Candidate MSC-Like Cells from Umbilical Cord. Stem Cells, 2003, 21(1): 105-10

Buzanska L. et al., Neural stem cell line derived from human umbilical cord blood – morphological and functional properties. J. Neurochem., 2003, 85 Supp 2:33

Frassoni F. et al., Cord blood transplantation provides better reconstitution of hematopoietic reservoir as compared to bone marrow transplantation. Blood. 2003 Aug 1;102(3):1138-41.

Broxmeyer H.E., Srour E.F., Hangoc G., Cooper S., Anderson S.A., Bodine D.M., High-efficiency recovery of functional hematopoietic progenitor and stem cells from human cord blood cryopreserved for 15 years. Proc. Natl. Acad. Sci. USA, 2003 Jan 21, 100(2): 645-50

Schmidt M, Carbonaro DA, Speckmann C, Wissler M, Bohnsack J, Elder M, Aronow BJ, Nolta JA, Kohn DB, von Kalle C. Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates. Nat Med. 2003 Apr, 9(4): 463-8

Barker J.N. et al., Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced intensity conditioning. Blood 2003 Sep 1;102(5):1915-9. Epub 2003 May 8.

Lee NS, Cheong HJ, Kim SJ, Kim SE, Kim CK, Lee KT, Park SK, Baick SH, Hong DS, Park HS, Won JH. Ex vivo purging of leukemia cells using tumor-necrosis-factor-related apoptosis-inducing ligand in hematopoietic stem cell transplantation. Leukemia, 2003 Jul;17(7):1375-83.

Lewis I.D.,Clinical and experimental uses of umbilical cord blood. Internal Medicine Journal, 2002, 32: 601-609

Barker J.N. et al., Umbilical cord blood transplantation: current state of the art. Current Opinion in Oncology, 2002, 14: 160-164

Sanchez-Ramos J.R., Neural cells derived from adult bone marrow and umbilical cord blood. J. Neurosci. Res., 2002, 69(6): 880-93

Bicknese A.R. et al., Human umbilical cord blood cells can be induced to express markers for neurons and glia. Cell Transplant, 2002, 11(3): 261-4

Buzanska L., Human cord blood-derived cells attain neuronal and glial features in vitro. J. Cell. Sci., 2002 May 15, 115(Pt 10): 2131-8

Jiang Y. et al., Pluripotency of mesenchymal stem cells derived from adult marrow. Nature, 2002, 418(6893):41-9

Goodwin H.S. et al., Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol. Blood Marrow Transplant, 2001, 7(11): 581-8

Fruchtman, S.M., Isola, L., Hurlet, A., Hurlet, A., Dracker, R., Richard, S., Singh, H., Goldman, B. and Emre, S. (2001), “Autologous cord blood infusion for severe aplastic anemia”, (SAA)”, Blood 98(11), Abstract #2872

Ballen K. et al., Current status of cord blood banking and transplantation in the United States and Europe. Biology of Blood and Marrow Transplantation, 2001, 7: 653-645

Barker J.N. et al., Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis. Blood, 2001, 97: 2957-2961

Moretta A. et al., Analysis of immune reconstitution in children undergoing cord blood transplantation. Exp. Hematol., 2001, 29: 371-379

Robmanith T. et al., Interleukin 3 improves the ex vivo expansion of primitive human cord blood progenitor cells and maintains the engrafment potential of SCID repopulating cells. Stem Cells, 2001, 19: 313-320

Lam A.C. et al., Preclinical ex vivo expansion of cord blood hematopoietic stem and progenitor cells: duration of culture; the media, serum supplements, and growth factors used; and engraftment in NOD/SCID mice. Transfusion, 2001: 1567-1576

Lewis I.D., Verfaillie C.M., Multilineage expansion potential of primitive hematopoietic progenitors. Superiority of umbilical cord blood compared to mobilized peripheral blood. Exp. Hematol., 2000, 28: 1087-9

Sanz G.F., Standardized, unrelated donor cord blood transplantation in adults with hematologic malignancies. Blood, 2001, 98 (8): 2332-2338

Laughlin M.J. et al., Hematopoietic engraftment and survival in adult recipients of umbilical cord blood from unrelated donors. N. Engl. J. Med., 2001, 344 (24): 1815-1822

Hows J.M., Status of umbilical cord blood transplantation in the year 2001.J. Clin. Pathol, 2001, 54: 428-434

Lennard A.L., Jackson G.H., Clinical review: Stem cell transplantation. BMJ, 2000, 321: 433-37

Lewis I.D., Verfaillie C.M., Multilineage expansion potential of primitive hematopoietic progenitors. Superiority of umbilical cord blood compared to mobilized peripheral blood. Exp. Hematol., 2000, 28: 1087-9

Lennard A.L., Jackson G.H., Clinical review: Stem cell transplantation. BMJ, 2000, 321: 433-37

Paquette R.L. et al., Ex vivo expanded unselected peripheral blood: progenitor cells reduce post transplantation neutropenia, thrombocytopenia, and anemia in patients with breast cancer. Blood, 2000, 96: 2385-90

Erices A. et al., Mesenchymal progenitor cells in human umbilical cord blood. British Journal of Haematology, 2000, 109: 235-242

McNiece I. et al., Increased expansion and differentiation of cord blood products using a two-step expansion culture. Exp. Hematol., 2000, 28: 1181-6

Colter D., Class R. et al., Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc. Natl Acad. Sci., 2000, 97 (7): 3213-18

Mugishima H., Harada K., Chin M., Suzuki T., Takagi K., Hayakawa S., Sato K., Klein J.P., Gale R.P., Effects of long-term cryopreservation on hematopoietic progenitor cells in umbilical cord blood. Bone Marrow Transplant; 1999 Feb, 23(4): 395-6

Ferreira E, Pasternak J, Bacal N, de Campos Guerra JC, Mitie Watanabe F. Autologous cord blood transplantation. Bone Marrow Transplant. 1999 Nov;24(9):1041

Shpall E.J. et al., Transplantation of adult and pediatric cancer patients with cord blood progenitors expanded ex vivo. Blood, 1999, 94: 712a

Reiffers J. et al., Abrogation of post-myeloablative chemotherapy neutropenia by ex vivo expanded autologous CD34 positive. Cells Lancet, 1999, 354: 1092-3

Mayani H., Lansdorp P., Biology of human umbilical cord blood - derived hematopoietic stem / progenitor cells. Stem Cells, 1998, 16: 153-65

Kohn DB et al., T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates. Nat Med. 1998 Jul, 4(7):775-80

Gluckman E., Rocha V., Boyer-Chamard A. et al. Outcome of cord-blood transplantation from related and unrelated donors.Eng. J. Med., 1997, 337 : 373-81

Laporte J.P., Gorin N., Rubinstein P. et al. Cord blood transplantation from unrelated donor in an adult with chronic myelogenous leukemia. Eng. J. Med., 1996, 335: 167-70

Kohn DB, Weinberg KI, Nolta JA, Heiss LN, Lenarsky C, Crooks GM, Hanley ME, Annett G, Brooks JS, el-Khoureiy A, et al. Engraftment of gene-modified umbilical cord blood cells in neonates with adenosine deaminase deficiency. Nat Med. 1995 Oct;1(10):1017-23.

Broxmeyer H. et al., Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults. Proc. Natl. Acad. Sci. USA, 1992, 89: 4109-4113

Gluckman E., Broxmeyer H., Auerbach A. et al., Hematopoietic reconstitution in a patient with Fanconi’s anemia by means of umbilical cord blood from an HLA-identical sibling. N. Eng. J. Med., 1989, 321: 1174-8